Diabetes Type Effect on Pancreas Transplant Outcome

Since 1994, transplant centers reported recipients as diabetes type 1 or type 2. Of 2000-2004 primary DD recipients, 7.2% SPK, 4.9% PAK and 4.3% PTA were classified by the reporting centers as type 2 (p=0.005).  For SPK, mean recipient age range was 46.1±8 years for type 2 and 40.1±8 years for type 1 (p=0.0001). Neither patient survival rates nor pancreas graft survival rates had statistically significant differences in SPK type 1 and type 2 cases.  The proportion of males recipients was higher for type 2 (69%)  vs. type 1 (59%) (p=0.002). Duration of diabetes prior to pancreas transplant was significantly shorter for type 2 (22.3±8 years) than type 1 (26.7±9 years). Since reporting of diabetes type is not always clear, the age of onset shows that only 5% reported onset after age 30, while 80% reported onset prior to age 21 and 95% before age 30 (Figure 16). By category, this distribution is seen is SPK and PAK, but PTA recipients had onset after age 30 at twice the rate. Age of onset did not impact patient survival for any category or pancreas survival for PAK or PTA, but in SPK pancreas GSRs were significantly lower for patients with very early onset of diabetes (Figures 17a and 17b).

Figure 16

Figure 17a

Figure 17b

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